About the two modes of Geant4 (Sequential and Multithreading)

Hello, I would like to know what are the main differences between sequential Geant4 and Multithreading Geant4?. Which Geant4 mode is most convenient to use?

_Geant4 Version:_11.2.1
_Operating System:_Windows 10
_Compiler/Version:_Visual Studio 2022
_CMake Version:_3.29.0-rc2