How does Geant4 compute the uncertainty of simulation results

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Geant4 Version:11.3.2
Operating System:ubunutu linux
Compiler/Version:gcc
CMake Version:


Does anyone with experience know how, in Command-based Scoring, one should calculate the uncertainty if a three-dimensional dose deposition matrix is obtained?

In other words, how does Geant4 compute the uncertainty of simulation results?