Geant4-DNA molecular Example Discrepancy

Dear geant4 user,

I used the ‘human_cell.mac’ file from the geant4-dna molecular example, configured all the settings to match those in the referenced paper. However, the yields of SSB and DSB obtained are much higher than the data in the literature. Does anyone know why? Could it be related to updates in G4data?(I executed the command in the terminal ./molecular -m humen_cell.mac -p 2)

Thank you!

this is my .mac example

/process/dna/e-SolvationSubType Meesungnoen2002
#/process/dna/e-SolvationSubType Ritchie1994
#/process/dna/e-SolvationSubType Terrisol1990

/run/verbose 1
/control/verbose 1

/world/worldSize 50 um
/cell/radiusSize 14 2.5 14 um
/scheduler/endTime 5.0 ns
/scheduler/maxNullTimeSteps 10000000
/dnageom/radicalKillDistance 9 nm
/dnageom/interactionDirectRange 3.5 angstrom

/dnageom/placementSize 75 75 75 nm
/dnageom/fractalScaling 75 75 75 nm
/dnageom/definitionFile geometries/cube-centred-X-8.txt
/dnageom/placementVolume turn geometries/turned_solenoid_750_withHistone.txt
/dnageom/placementVolume turntwist geometries/turned_twisted_solenoid_750_withHistone.txt true
/dnageom/placementVolume straight geometries/straight_solenoid_750_withHistone.txt

/dnadamage/directDamageLower 5 eV
/dnadamage/directDamageUpper 37.5 eV

/dnadamage/indirectOHBaseChance 1.0
/dnadamage/indirectOHStrandChance 0.405
/dnadamage/inductionOHChance 0.00

/dnadamage/indirectHBaseChance 1.0
/dnadamage/indirectHStrandChance 0.0
/dnadamage/inductionHChance 0.00

/dnadamage/indirectEaqBaseChance 1.0
/dnadamage/indirectEaqStrandChance 0.0
/dnadamage/inductionEaqChance 0.00

/chromosome/add cell ellipse 7100 2500 7100 0 0 0 nm 0 0 0
#/chromosome/add cell sphere 3000 0 0 0 nm

/run/initialize
/run/printProgress 10

Source Geometry

/gps/pos/type Plane
/gps/pos/shape Circle
/gps/pos/centre 0 3000 0 nm
/gps/pos/rot1 0 0 1
/gps/pos/rot2 1 0 0
/gps/pos/radius 3000 nm
/gps/direction 0 -1 0

Source Energy

/gps/particle proton

#/analysisDNA/fileName 50MeV
/gps/energy 68.5 MeV
/run/beamOn 1000

1 Like

Dear,

Can you verify the same parameters used as the referenced paper ? Can you precise the data in the literature, please ? Thanks

I have used the same parameters as paper ‘Simulation of DNA damage using Geant4-DNA: an overview of the
“molecularDNA” example application’,endTime、radicalKillDistance、interactionDirectRange、indirectOHStrandChance、directDamageLower(Upper) is same as this paper.
d253968f728598c6a25cf6618541359

Thanks! The results are similar with this : Reproduce result - moleculardna